Aaron Burr, serving as Vice President under Thomas Jefferson, famously dueled and killed Alexander Hamilton, a former Secretary of the Treasury, in 1804.
John Tyler became the first Vice President to ascend to the presidency following the death of President William Henry Harrison in 1841.
Charles Curtis, serving as Vice President under Herbert Hoover, was of Native American Kaw heritage, making him the first person of non-European ancestry to hold the office.
Dan Quayle, elected as Vice President under George H.W. Bush, was one of the youngest Vice President-elects in history at the age of 41.
Joe Biden, serving as Vice President under Barack Obama, became the oldest person elected to the Vice Presidency and later, in 2021, the oldest person to assume the presidency.
Mike Pence, serving as Vice President under Donald Trump, was the first Vice President to invoke the 25th Amendment to the Constitution, initiating the process to declare the President unfit for duty.
Spiro Agnew, serving as Vice President under Richard Nixon, resigned from office in 1973 after being investigated for bribery, tax evasion, and conspiracy.
Alben Barkley, serving as Vice President under Harry S. Truman, popularized the term "Veep" as a nickname for the Vice President, which is now commonly used in American political vernacular.
Nelson Rockefeller, who served as Vice President under Gerald Ford, never held elected office as Vice President or President, having been appointed to the former position after Ford assumed the presidency following Richard Nixon's resignation.
George Clinton, who served as Vice President under both Thomas Jefferson and James Madison, holds the record for being the longest-serving Vice President, with a total of over eight years in office.